Heritability and Familial Aggregation of Refractive Error in the Old Order Amish

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Heritability of refractive error and familial aggregation of myopia in an elderly American population.

PURPOSE To determine the heritability of refractive error and the familial aggregation of myopia in an older population. METHODS Seven hundred fifty-nine siblings (mean age, 73.4 years) in 241 families were recruited from the Salisbury Eye Evaluation (SEE) Study in eastern Maryland. Refractive error was determined by noncycloplegic subjective refraction (if presenting distance visual acuity w...

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Diabetes in the Old Order Amish

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Familial aggregation and heritability of pyloric stenosis.

CONTEXT Pyloric stenosis is the most common condition requiring surgery in the first months of life. Case reports have suggested familial aggregation, but to what extent this is caused by common environment or inheritance is unknown. OBJECTIVES To investigate familial aggregation of pyloric stenosis from monozygotic twins to fourth-generation relatives according to sex and maternal and patern...

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A canine model of inherited myopia: familial aggregation of refractive error in labrador retrievers.

PURPOSE To determine whether the distribution of naturally occurring myopia in Labrador Retrievers has a genetic component. METHODS Pedigree records of a large canine family were analyzed. Pure Labrador Retrievers, 1 to 8 years of age, free of ocular disease, and available for testing were studied. Refractive error was measured by cycloplegic retinoscopy in both eyes. The family included mati...

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Comparison of BMI and Physical Activity Between Old Order Amish Children and Non-Amish Children

OBJECTIVE The Old Order Amish (OOA) is a conservative Christian sect of European origin living in Pennsylvania. Diabetes is rare in adult OOA despite a mean BMI rivaling that in the general U.S. non-Hispanic white population. The current study examines childhood factors that may contribute to the low prevalence of diabetes in the OOA by comparing OOA children aged 8-19 years with National Healt...

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ژورنال

عنوان ژورنال: Investigative Opthalmology & Visual Science

سال: 2007

ISSN: 1552-5783

DOI: 10.1167/iovs.06-1388